Shizuo Yamada Selected Research

Muscarinic Receptors (Muscarinic Acetylcholine Receptor)

12/2021	Muscarinic receptor binding activity in rat tissues by vibegron and prediction of its receptor occupancy levels in the human bladder.
1/2021	Possible Involvement of Muscarinic Receptor Blockade in Mirabegron Therapy for Patients with Overactive Bladder.
1/2020	Acanthopanax senticosus Root Extract Exerts Dual Action on Mouse Ileal Smooth Muscle Function, Leading to Modulation of Gastrointestinal Motility.
1/2014	Muscarinic receptor binding of the novel radioligand, [3h]imidafenacin in the human bladder and parotid gland.
1/2013	Beneficial effects of Gosha-jinki-gan and green tea extract in rats with chemical cystitis.
9/2012	Characterization of bladder selectivity of antimuscarinic agents on the basis of in vivo drug-receptor binding.
9/2011	Muscarinic Receptor Binding of Imidafenacin in the Human Bladder Mucosa and Detrusor and Parotid Gland.
8/2011	α1-Adrenoceptors and muscarinic receptors in voiding function - binding characteristics of therapeutic agents in relation to the pharmacokinetics.
2/2011	Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder.
1/2011	Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate.

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Shizuo Yamada Research Topics

Disease

24	Overactive Urinary Bladder (Overactive Bladder) 12/2021 - 11/2004
15	Asthma (Bronchial Asthma) 01/2012 - 12/2004
13	Phototoxic Dermatitis (Phototoxicity) 12/2013 - 03/2008
13	Chronic Obstructive Pulmonary Disease (COPD) 01/2012 - 05/2004
9	Inflammation (Inflammations) 04/2014 - 05/2004
7	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 03/2022 - 07/2007
6	Lower Urinary Tract Symptoms 05/2018 - 04/2009
5	Body Weight (Weight, Body) 12/2019 - 12/2009
4	Cystitis 01/2014 - 10/2010
3	Fatigue 01/2020 - 01/2018
3	Ischemia 04/2014 - 12/2002
3	Achlorhydria (Hypochlorhydria) 01/2013 - 04/2012
3	Type 2 Diabetes Mellitus (MODY) 01/2011 - 12/2004
3	Lung Diseases (Lung Disease) 09/2007 - 12/2004
2	Mitochondrial Diseases (Mitochondrial Disease) 05/2022 - 02/2021
2	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2022 - 01/2020
2	Neuroinflammatory Diseases 05/2022 - 02/2021
2	Dementia (Dementias) 05/2022 - 01/2020
2	Constipation 08/2019 - 01/2018
2	Infarction (Infarctions) 04/2014 - 02/2007
2	Brain Ischemia (Cerebral Ischemia) 04/2014 - 12/2002
2	Atherosclerosis 01/2014 - 07/2012
2	Idiopathic Pulmonary Fibrosis 06/2013 - 03/2013
2	Pneumonia (Pneumonitis) 06/2013 - 01/2010
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 06/2013 - 06/2012
2	Pain (Aches) 02/2013 - 01/2011
2	Prostatic Neoplasms (Prostate Cancer) 01/2013 - 10/2011
2	Insulinoma 01/2011 - 11/2008
2	Mental Disorders (Mental Disorder) 01/2010 - 08/2005
2	Urinary Bladder Neck Obstruction (Bladder Neck Obstruction) 02/2009 - 02/2007
1	Major Depressive Disorder (Major Depressive Disorders) 05/2022
1	Schizophrenia (Dementia Praecox) 05/2022
1	Alzheimer Disease (Alzheimer's Disease) 12/2021
1	Pruritus (Itching) 05/2021
1	Hypersensitivity (Allergy) 05/2021
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/2021

Drug/Important Bio-Agent (IBA)

23	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 12/2021 - 11/2004
20	Pharmaceutical PreparationsIBA 01/2015 - 12/2004
10	Muscarinic AntagonistsIBA 01/2021 - 01/2006
8	oxybutynin (Tavor)FDA LinkGeneric 09/2012 - 11/2004
6	saw palmetto extractIBA 03/2022 - 03/2009
6	AntigensIBA 05/2021 - 01/2011
6	Cholinergic Agents (Cholinergics)IBA 01/2014 - 05/2008
6	Neutral RedIBA 12/2013 - 03/2008
6	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2013 - 08/2008
6	PowdersIBA 06/2013 - 06/2009
5	Cholinergic Antagonists (Anticholinergics)IBA 01/2019 - 07/2006
5	imidafenacinIBA 01/2017 - 02/2011
5	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA 06/2012 - 09/2007
5	Arg(15,20,21)-Leu(17)- vasoactive intestinal peptide-GRRIBA 11/2010 - 12/2004
4	Solifenacin Succinate FDA Link 01/2016 - 08/2009
4	Purinergic Receptors (Receptors, Purine)IBA 01/2014 - 05/2008
4	Therapeutic UsesIBA 01/2014 - 07/2007
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2014 - 05/2008
4	Biomarkers (Surrogate Marker)IBA 06/2013 - 06/2009
4	DNA (Deoxyribonucleic Acid)IBA 03/2013 - 10/2008
4	Tolterodine Tartrate (Detrol)FDA Link 09/2012 - 01/2006
4	tranilastIBA 06/2012 - 02/2010
3	MetalsIBA 05/2022 - 01/2020
3	nobiletinIBA 12/2021 - 09/2011
3	CytokinesIBA 01/2014 - 01/2013
3	Dipyridamole (Persantine)FDA LinkGeneric 01/2013 - 04/2012
2	Amyloid (Amyloid Fibrils)IBA 05/2022 - 09/2011
2	Adrenergic Receptors (Adrenergic Receptor)IBA 12/2021 - 08/2011
2	EnzymesIBA 01/2021 - 09/2013
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019 - 01/2010
2	TeaIBA 01/2015 - 01/2013
2	Neuroprotective AgentsIBA 04/2014 - 12/2002
2	flavoneIBA 04/2014 - 09/2011
2	pirfenidoneIBA 06/2013 - 03/2013
2	eviprostatIBA 03/2013 - 07/2012
2	SolutionsIBA 02/2013 - 01/2011
2	AndrogensIBA 01/2013 - 10/2011
2	Omeprazole (Prilosec)FDA LinkGeneric 01/2013 - 04/2012
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2012 - 08/2009
2	O,O-diisopropyl-S-benzylthiophosphate (IBP)IBA 09/2011 - 09/2010
2	darifenacin FDA Link 08/2011 - 02/2007
2	silodosin FDA Link 08/2011 - 07/2007
2	propiverineIBA 08/2011 - 06/2007
2	Drug Receptors (Drug Receptor)IBA 08/2011 - 01/2010
2	Tamsulosin (Flomax)FDA LinkGeneric 08/2011 - 07/2007
2	Anti-Allergic Agents (Antiallergic Agents)IBA 02/2011 - 02/2010
2	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 01/2011 - 12/2004
2	Peptides (Polypeptides)IBA 01/2011 - 12/2004
2	SmokeIBA 11/2010 - 12/2004
2	OvalbuminIBA 01/2010 - 06/2009
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2010 - 08/2005
2	Protease Inhibitors (Protease Inhibitor)IBA 08/2009 - 05/2004
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 06/2009 - 11/2008
2	1,4-dihydropyridine (dihydropyridine)IBA 04/2009 - 03/2008
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2008 - 03/2008
1	SynucleinsIBA 05/2022
1	N- (4- ((5- (hydroxy(phenyl)methyl)pyrrolidin- 2- yl)methyl)phenyl)- 4- oxo- 4,6,7,8- tetrahydropyrrolo(1,2- a)pyrimidine- 6- carboxamideIBA 12/2021
1	p-Methoxy-N-methylphenethylamineIBA 05/2021
1	Muramidase (Lysozyme)IBA 05/2021

Therapy/Procedure

10	Therapeutics 01/2021 - 12/2004
7	Oral Administration 05/2021 - 02/2007
3	Dry Powder Inhalers 01/2011 - 08/2009
2	Drug Therapy (Chemotherapy) 12/2021 - 08/2009
2	Respiratory Therapy (Therapy, Respiratory) 01/2010 - 08/2009